This indispensable guide provides step-by-step assistance to researchers applying for biobehavioral and psychosocial research funding from the Public Health Service. The first section examines grantsmanship and the review process. Chapters explore the process for determining research opportunities and priorities and how scientific merit is established for research applications. The second section offers a step-by-step guide to completing the PHS 398 research application and includes examples. Chapters offer insights into developing a theoretical framework and writing testable hypothesis and much more.