The topics of the conference are very timely as the phenomenal advancements of computing facilities have pierced every segment of science, engineering and technology to find solutions of complex problems with ever-increasing accuracy and are helping academicians, scientists, researchers, engineers, software developers, and practitioners achieve significant progress in the solution of previously-unsolved problems. This trend is particularly significant in fluid and thermo-fluid mechanics, energy, software engineering, drug delivery systems, system biology, bioinformatics, etc., where computer-based simulation and optimization (online and offline) have found extensive applications. The primary goal of the conference is to promote the applications of modeling, optimization methods and computing methods in the general area of science and engineering.