This book is dedicated to the first ten years of Chaos and Complexity Letters - International Journal of Dynamical Systems Research. This journal was born to collect and disseminate complexity science related information to anybody interested in the topic; to speed up the evolutionary development of complexity science; to extend its interactions crossing over disciplines, levels of knowledge and geography; and to foster finding new pathways in research and new applications. The structure of CCL was specifically designed to add value to the trans-disciplinary approach while, at the same time, differentiating the epistemology of different contributions. In this enterprise we were sustained and inspired by two great companions that in different ways shared our project during its prehistory: Ilya Prigogine and Francisco Varela. This book collects 16 papers appeared on the first ten volumes of Chaos and Complexity Letters. They range from the life sciences, to STEM and economy, in accordance with the interdisciplinary mission of the journal. A special highlight starts with Acceleration and entropy: a macroscopic analogue of the twin paradox, possibly the last paper written by the Nobel Prize Ilya Prigogine with Gonzalo Ordonez. Important academic specialists who wrote in our scientific journal passed away. For example, Walter Freeman, Tullio Minelli, Ilya Prigogine, and Joseph P. Zbilut. This special issue is also dedicated to them. We are in opinion that their trajectories in life and research designed some contours of the shape of a new science to come.