This book is an investigation of the ideological dimensions of the disciplinary discourses on science in line with the scholarly tradition of historical epistemology. It offers a programmatic treatment of the political-epistemological problematic along three entangled lines of inquiry: socio-historical, epistemological and historiographical. The book aims for a meta-level integration of the existing scholarship on the social and cultural history of science in order to consider the ways in which struggles for hegemony have constantly informed scientific discourses. This problematic is of primary relevance for scholars in Science Studies, philosophers, historians and sociologists of science, but would also be relevant for anybody interested in scientific culture and political theory.