A rapidly developing field, computer simulation methods continue to find broader application and scope in an ever widening range of fields including physics, chemistry, biology, physiology, and pharmacology. Unfortunately, Monte Carlo and molecular dynamics methods, the most widely used methods for modeling statistical mechanical systems, are notoriously difficult to handle on the computer when the system has many degrees of freedom such as in spin glass systems and biomolecular systems. This book offers in-depth coverage of the generalized ensemble algorithm and its application to solve the difficulties associated with simulation techniques for complex problems.