In this edition, Dr. Offit, a world-recognized leader in this emerging field, provides an updated and expanded treatment of his seminal text on the clinical management associated with syndromes of cancer predisposition, with a thorough review of the relevant molecular genetics. The first part of the book outlines the scope of this field and the basic underlying concepts. The next chapters review the syndromes of cancer predisposition. Dr. Offit then discusses quantitative methods, approaches to genetic testing, reproductive risk counseling, and the critical psychological, ethical, and legal challenges of clinical cancer genetics.