On June 3, 1513, ships commanded by Juan Ponce de Leon were attacked by a group of Calusa Indians in one of the first hostile encounters recorded between Europeans and American Indians. Over the next four centuries, fundamental differences would cause these two disparate cultures to clash numerous times with untold loss of life and property.

From the 1500s through 1901, this comprehensive reference book details individual armed conflicts between Native Americans and Europeans. Chronologically arranged entries include information such as origin of the European party, Indian tribe involved (if known), location of the skirmish and number of casualties. The establishments of various forts are also given within the chronology. An appendix provides a brief summary of related events after 1901.