This book provides a plethora of information about global arsenic (As) contamination and the challenges for environment. Arsenic is a naturally occurring metalloid that is widely distributed in water, soil, air and biota from natural and anthropogenic sources. Arsenic has been found in drinking water in over 100 countries worldwide, which caused a major public health issue including: cardiovascular disorders, diabetes, and cancers of various organs - these are some of the general health effects of As exposure. Exposure of plants to As, even at very low concentrations, can cause many morphological, physiological, and biochemical changes. The recent research on As in the water-soil-plant-human systems indicates that As toxicity to plants varies with As speciation in plants, type of plant species and with other soil factors controlling As accumulation in plants. In recent years, the development of efficient green chemistry methods for detoxification of trace metal poisoning has become a major focus of researchers. It has been investigated in order to find an eco-friendly and recyclable technique for the removal of As contamination from the natural resources.