This Element examines the emergence of comprehensive plague management systems in early modern France. While the historiography on plague argues that the plague of Provence in the 1720s represented the development of a new and 'modern' form of public health care under the control of the absolutist monarchy, it shows that the key elements in this system were established centuries earlier because of the actions of urban governments. It moves away from taking a medical focus on plague to examine the institutions that managed disease control in early modern France. In doing so, it seeks to provide a wider context of French plague care to better understand the systems used at Provence in the 1720s. It shows that the French developed a polycentric system of plague care which drew on the input of numerous actors combat the disease.