This book constitutes the refereed proceedings of the Second MICCAI Workshop on Medical Content-Based Retrieval for Clinical Decision Support, MCBR-CBS 2011, held in Toronto, Canada, in September 2011.

The 11 revised full papers presented together with 2 invited talks were carefully reviewed and selected from 17 submissions. The papers are divided on several topics on medical image retrieval with textual approaches, visual word based approaches, applications and multidimensional retrieval.