This transdisciplinary book investigates the profound repercussions of living in a post-truth world in which 'alternative facts' and post-truth knowledge claims, often bordering on the absurd, have replaced the real in the collective imagination of millions of people around the planet. Through discussions on climate change denial, the anti-vaccination movement, the January 6th Insurrection and the Russia-Ukraine War, this study explores the gravity of the current 'infodemic,' or the increasing inability of a large segment of the population to distinguish between reality and misrepresentation, and the destabilizing impact this infodemic has on democratic models of governance around the globe, coinciding with the rise of autocratic forms of populism.