This book constitutes the refereed proceedings of the 18th International Conference on Computer-Aided Systems Theory,  EUROCAST 2022, held in Las Palmas de Gran Canaria, Spain, during February 20–25, 2022.   The 77 full papers included in this book were carefully reviewed and selected from 110 submissions. They were organized in topical sections as follows: Systems Theory and Applications, Theory and Applications of Metaheuristic Algorithms, Model-Based System Design, Verification and Simulation, Applications of Signal Processing Technology, Artificial Intelligence and Data Mining for Intelligent Transportation Systems and Smart Mobility, Computer Vision, Machine Learning for Image Analysis and Applications, Computer and Systems Based Methods and Electronic Technologies in Medicine, Systems in Industrial Robotics, Automation and IoT, Systems Thinking. Relevance for Technology, Science and Management Professionals.