Global population by 2050 is predicted to be over 9 billion and accordingly, the production systems will demolish about 140 billion tons per year of minerals, ores, fossil fuels and biomass, i.e., thrice of the current need, and the food production itself has to be doubled. Optimized resource usage, lifecycle management, and reduced carbon emission have become a priority for agri-food businesses today, and circular economy (CE) helps for a sustainable and flexible way to grow without exhausting primary materials, and it thinks beyond recycling and resource usage. The word CE best relates to the resource and efficiency management, 6Rs, closed-loop production systems, zero waste and lifecycle engineering, reduced overconsumption of resources and waste generation, enriched system redesign and business model innovation, thereby leading to sustainable development goals. In this light, the book calls for theoretical and empirically sound contributions that are focused on the different aspects of the circular economy, 6R’s, sustainable production and consumption, closed-loop systems, etc. in the agri-food sector.