As a core part of the central nervous system, the spinal cord has a distinctive role in the etiology and exacerbation of common and less common neurologic disorders. This issue of Neurologic Clinics will look at the spinal cord's involvement in disorders arising generally in the CNS, as well as disorders based within the cord itself. Articles include: Spinal cord: A review of functional neuroanatomy; Infections of spinal cord; Multiple sclerosis and spinal cord; Transverse myelitis; Neuromyelitis optica; Vascular disorders of spinal cord; Spine and spinal cord trauma; Imaging of spinal cord: General principles; Toxic, nutritional, and metabolic deficiencies of spinal cord; Spinal cord: Motor neuron diseases; Spinal cord tumors: New views and future directions; Spinal cord and spasticity: A mechanistic view; Cervical spondylosis and stenosis; Autonomic nervous system disorders and spinal cord; Stiff person syndrome: What is new?; Sleep disorders in patients with spinal cord injury.