This manual offers a unique, extensively class tested approach to introductory biology laboratory. A full range of activities show how basic biological concepts can be applied to a wide variety of plants, animals, and microorganisms. The exercises are designed to stimulate curiosity and provide understanding of the processes of investigation that are basic to science. This helps students to: 1) gain practical experience that will help them understand lecture concepts, 2) acquire the basic knowledge needed to make informed decisions about biological questions that arise in everyday life, 3) develop the problem-solving skills that will lead to success in school and in a competitive job market, and 4) learn to work effectively and productively as a member of a team.