While several experimental and computational techniques are available to determine native protein structures, researchers have only recently addressed the problem of characterizing the structure and dynamic of proteins in non-native states. Restrained Simulations of Protein Folding describes computational techniques developed to define the many states that proteins populate in the cell. This book provides novel techniques for determining the effects of protein flexibility, membrane proteins, structural information, and more. It text emphasizes the use of experimental measurements as restraints to generate protein conformations that are consistent with observations.