This anthology broadly examines the interrelated roles of art, science, and experimentation in Nietzsche's philosophical project. It is divided into two parts, the first organized around the theme of experimentally reconceiving our world, the second investigating the aforementioned subjects in Nietzsche’s “free spirit” or “middle period” works. Together, the essays comprising the book underscore Nietzsche’s concern that experimentation with values ultimately provide humankind with a new “wherefore” or purpose. Wide-ranging in its scope, this volume brings together a diverse group of scholars working in both the analytic and continental traditions to provide original insights into Nietzsche’s thought. A unique contribution to the scholarship, it deepens understanding of the relationship between Nietzsche’s critiques of art and science, the role this relationship plays in his futural thought, and the experimental, life-affirming practices that his free spirit project may enable toward the transfiguration of humankind.