The progressive collapse of part of Ronan Point tower block in east London in 1968 was a very significant event in structural engineering in relation to the understanding of disproportionate damage to structures. There have been extensive research and investigations since then, including full-scale structural load tests on a block in Liverpool, which are taken fully into account in this handbook. New guidance on the structural assessment and strengthening options for large panel system (LPS) dwelling blocks is presented, focusing primarily upon their resistance to accidental loading associated with gas explosions. and supported by extensive background information.