This book is a collection of selected papers submitted to the 2022 International Conference on Intelligent Systems Design and Engineering Applications organized in Tokyo, Japan, May 13-15, 2022 (ISDEA2022). The book is organized according to the conference’s five major themes, including 1) Theory and Application of Intelligent Computing, 2) Intelligent Information System and Management Decision, 3) Artificial Intelligence and Robots, 4) Mechanical design and intelligent manufacturing and 5) Intelligent control and detection technology.