There are not many books published about esophageal cancer. Esophageal cancer is an entity that must be treated from a multimodal approach. Recent advances in diagnosis, anesthetic aspects and perioperative care, among others, are summarized in this book. This book is written in a simple way and intends to cover the main aspects of this type of cancer. It incorporates the latest evidence about the diagnosis, management and treatment of esophageal cancer from a multimodal point of view. Epidemiologists, gastroenterologists, oncologists and surgeons have all participated in the elaboration of this book. It is divided into ten chapters, describing all esophageal cancer topics and each chapter has been written by recognized experts in this field. Complex content and results have been made reader-friendly and easily understandable. This book is especially useful for residents and fellows because it highlights the important principles for managing these patients. The chapter about surgery is written by a surgeon who is currently considered the best in esophageal cancer, Prof. Simon Law. Also, the oncological content has been written highlighting the latest practical and clinical evidence. The reader can use this book as a practical guideline when addressing patients with esophageal cancer.