This book constitutes the refereed proceedings of the 10th International Workshop on Augmented Environments for Computer-Assisted Interventions, held in conjunction with MICCAI 2015, in Munich, Germany in October 2015. The 15 revised full papers presented were carefully reviewed and selected from 21 submissions. The objective of the AE-CAI workshop was to attract scientific contributions that offer solutions to the technical problems in the area of augmented and virtual environments for computer-assisted interventions, and to provide a venue for dissemination of papers describing both complete systems and clinical applications.