The worldwide population of adults ages 60 and over has rapidly become the fastest growing age group, making the study of ageism a pressing social issue. Collectively, contributors to this issue draw on strong theoretical traditions and sophisticated multi-methods (cross-sectional, longitudinal, and experimental) to offer empirical evidence toward a greater understanding of the role of ageism in health and employment contexts. This special issue sets the stage for the next wave of international research on ageism across the lifecycle and for making greater progress on designing and implementing effective interventions and public policies supporting older adults and positive intergenerational relations.