The multi-faceted issue of antimicrobial resistance has fast gained momentum and emerged as a potential global threat. An effort has been made through this compilation, to foray into the realm of renegade microbes that have threatened to wreak havoc worldwide. The contributory papers are descriptive of the incidences of resistant pathogens in the health care sector, agriculture, environment and food, and mechanisms of their evolved resilience. Alternative methods to curb the menace and strategies that might help mitigate the situation have also been discussed and reviewed.