This work consists of contributions by professionals from clinical areas, health care management, payer institutions, information technology industry, government, and health care quality research. The chapters are a cross-section of various business perspectives of health information technologies. The work covers the challenges facing the widespread implementation of information technology, possible solutions to economic, structural, cultural, and institutional barriers in the use of these technologies. It presents real-world examples of information technologies that can be used as business models of applied clinical and business solutions to improve health care quality.