Set in the tiny town of Lake Belle Reve, Mississippi, the Ghost Brothers' story centres on two sets of brothers: the ghosts of Jack and Andy, dead in an apparent murder/suicide, and their nephews, the living Frank and Drake, who seem to be headed toward the same downward spiral as their uncles. Joe, younger brother of Jack and Andy, father of Frank and Drake, has decided it's time to reveal his own terrible secret at the site of the tragedy, before it's too late.