This issue of Anesthesiology Clinics focuses on Pharmacology. Editor Alan Kaye has assembled an expert team of authors on topics such as: Ketorolac, Oxymorphone and Tapentadol; Anticoagulation and Neuraxial/Peripheral Anesthesia; Pharmacologic Update on Antiemetics: Total parenteral nutrition/enteral nutrition in the ICU, Evolving Concepts; Reversal of Anticoagulants and Anesthesia Considerations; Non-opioids Intravenous or Oral Analgesics for Perioperative Pain Management, Update; Uterotonic Medications and Anesthesia Considerations: oxytocin, misoprostol, methylergonovine, carboprost; Pulmonary Vascular Mediating Drugs, Evolving Concepts; Alpha 2 Modulators and Anesthesia Considerations; Pharmacologic Considerations of Anesthetic Agents in the Obese Patient; Pharmacologic Considerations of Anesthetic Agents in the Geriatric Patient; Pharmacologic Considerations of Anesthetic Agents in the Pediatric Patient; Anesthesia CV Drug Update; Pharmacogenomics: Anesthesia; Pharmacogenomics: Pain; Novel anticoagulants; Novel anesthetic agents; Novel opioids; Pharmacology of Newer Local anesthetics; Pharmacology of Nonsteroidal Antiinflammatory and Steroid Medications. Implications for Anesthesia or Unique Associated Risks; Pharmacology of Octreotide. Implications for Anesthesia and Associated Risks.