This text chronicles the next advances in our knowledge of psychiatric neuroscience. It uses a teaching methodology that integrates the clinical aspects of psychiatric disorders with their neurobiology. It begins with by looking at functional neural circuitry and neural signalling pathways, and then presents current knowledge on the neuroatomic and neurochemical mechanisms underlying schizophrenia, addiction, anxiety,depression, bipolar disorder, and dementia/Alzheimer's disease. Each chapter focuses on a particular disorder and features the same four divisions - clinical presentation, neural circuitry, signalling pathways, and psychopharmacology.