This collection of articles focuses on areas of general medicine which are presented to clinicians at all levels in the profession. Some of the subjects discussed include; vitamin B12 deficiency, viral meningitis, acute altitude illnesses, assessment and management of alcohol use disorders and paracetamol poisoning, non-cardiovascular effects associated with statins and Guillain-Barre syndrome. Some of the other medical issues discussed include managing health problems in people with intellectual disabilities and adults with Down s syndrome and issues relating to sickle cell disease.