This state-of-the science, multidisciplinary Annual Review of Gerontology and Geriatrics provides a comprehensive examination of critical issues on resilience in a variety of life domains central to the well-being of older persons. It examines the role of resilience in determining adjustment and function in the domains of health, grief and bereavement, physical activity and functioning, spirituality, work, retirement, intellectual/cognitive functioning, coping with life events, care giving, and mental health interventions.