An estimated 11,000 spinal cord injuries occur each year in the United States and more than 200,000 Americans suffer from maladies associated with spinal cord injury. This includes paralysis, bowel and bladder dysfunction, sexual dysfunction, respiratory impairment, temperature regulation problems, and chronic pain. During the last two decades, longstanding beliefs about the inability of the adult central nervous system to heal itself have been eroded by the flood of new information from research in the neurosciences and related fields. However, there are still no cures and the challenge of restoring function in the wake of spinal cord injuries remains extremely complex.


Spinal Cord Injury examines the future directions for research with the goal to accelerate the development of cures for spinal cord injuries. While many of the recommendations are framed within the context of the specific needs articulated by the New York Spinal Cord Injury Research Board, the Institute of Medicine's panel of experts looked very broadly at research priorities relating to future directions for the field in general and make recommendations to strengthen and coordinate the existing infrastructure. Funders at federal and state agencies, academic organizations, pharmaceutical and device companies, and non-profit organizations will all find this book to be an essential resource as they examine their opportunities.


Table of Contents


Front Matter
Executive Summary
1 Introduction
2 Progression of Spinal Cord Injury
3 Tools for Assessing Spinal Cord Injury and Repair
4 Current Therapeutic Interventions
5 Progress Toward Neuronal Repair and Regeneration
6 Developing New Therapeutic Interventions: From the Laboratory to
the Clinic
7 Research Organization: Creating an Environment to Accelerate
Progress
8 State Programs in Spinal Cord Injury
Appendix A Study Process
Appendix B Acronyms
Appendix C Glossary of Major Terms
Appendix D Tools to Assess Spinal Cord Injury Outcomes
Appendix E Clinical Trials of Methylprednisolone
Appendix F Examples of Alternative Therapies
Appendix G Spinal Cord Injury Clinical Trials Published from 1998
to 2003
Appendix H Legislation Sponsoring State Spinal Cord Injury Research
Appendix I Committee and Staff Biographies
Index