This volume includes the latest developments, both in research and the clinic. Published in Association with the European and American Committees for Treatment and Research in Multiple Sclerosis (ECTRIMS & ACTRIMS). Following on from three previous books in the Frontiers of Multiple Sclerosis series the editors have selected a range of further subjects for analysis This volume includes the latest developments, both in research and the clinic from a range of internationally renowned contributors. Published nor the first time in association with ACTRIMS as well as with ECTRIMS, this book is a welcome addition to the neurologist's library.