This volume contains the proceedings of the 10th International Conference on Tools and Algorithms for the Construction and Analysis of Systems (TACAS 2004). TACAS 2004 took place in Barcelona, Spain, from March 29th to April 2nd, as part of the 7th European Joint Conferences on Theory and Practice of Software (ETAPS 2004), whose aims, organization, and history are detailed in a foreword by the ETAPS Steering Committee Chair, Jos´ e Luiz Fiadeiro. TACAS is a forum for researchers, developers, and users interested in ri- rously based tools for the construction and analysis of systems. The conference serves to bridge the gaps between di?erent communities including, but not - mited to, those devoted to formal methods, software and hardware veri?cation, static analysis, programming languages, software engineering, real-time systems, and communication protocols that share common interests in, and techniques for, tool development. In particular, by providing a venue for the discussion of common problems, heuristics, algorithms, data structures, and methodologies, TACAS aims to support researchers in their quest to improve the utility, rel- bility, ?exibility, and e?ciency of tools for building systems. TACASseekstheoreticalpaperswithaclearlinktotoolconstruction,papers describingrelevantalgorithmsandpracticalaspectsoftheirimplementation,- pers giving descriptions of tools and associated methodologies, and case studies with a conceptual message.