Depression is a common worldwide mental illness, and one of the leading causes of disability. It is not exclusive for an age, social or income level. Antidepressants are used as a pharmacological treatment for depression. Currently available antidepressants have several limitations including a long time lag for treatment response, modest rates of efficacy and the side effects associated with its use. This book examines the different perspectives, medical uses and health implications that antidepressants have on patients.