The Mixtec civilization (of Oaxaca, Mexico) is one of the most interesting to survive from pre-colonial Mesoamerica. Among its characteristic products were highly artistic pictographic codices depicting the history and dynasties of its city-states. This handbook surveys and describes the illustrated Mixtec manuscripts that survive in Europe, the United States and Mexico, outlines the history of their decipherment, current questions, discussions and methodologies relating to readings, social organisation, religion and historical drama, and surveys the six centuries of Mixtec history covered in the texts.