Written by over 70 internationally renowned experts, the Fourth Edition of this premier reference provides comprehensive, current information on the genetics, pathophysiology, diagnosis, medical and surgical treatment, and behavioral and psychologic concomitants of common and uncommon movement disorders, including Parkinson's disease, other neurodegenerative diseases, tremor, dystonia, Tourette syndrome, Huntington's disease, and ataxia. This edition includes new information on mechanisms and prevention of cell death (neuroprotection), psychiatric disorders in Parkinson's disease, botulinum toxin therapy for movement disorders and spasticity, and ancillary drugs that prolong the effectiveness of traditional pharmacotherapies. Chapters on surgery discuss deep brain stimulation and neural and stem cell transplantation.