Transgenic and knockout mutations provide an important means for understanding gene function, as well as for developing therapies for genetic diseases. This engaging and informative book discusses the many advances in the field of transgenic technology that have enabled researchers to bring about various changes in the mouse genome. Equal emphasis is given to both the principles of transgenic and knockout methods and their applications. A clear and concise format provides researchers with a comprehensive review of the behavioral paradigms appropriate for analyzing mouse phenotypes.





What's Wrong with My Mouse? explains the differences between transgenic knockout mice and their wild-type controls, while providing critical information about gene function and expression. This volume recognizes that newly identified genes can provide useful insights into brain functioning, including brain malfunctioning in disease states. Written by a world-renowned expert in the field, the material also covers:


? How to generate a transgenic or knockout mouse


? functions (open field, holeboard, rotarod, balance, grip, circadian activity, etc.)


? Sensory abilities (olfaction, vision, hearing, taste, touch, nociception)


? Reproductive behavior, social behavior, and emotional behavior





Researchers in neuroscience, pharmacology, genetics, developmental biology, and cell biology will all find this book essential reading.