This book discusses how scientific and other types of cognition make use of models, abduction, and explanatory reasoning in order to produce important, innovative, and possibly creative changes in theories and concepts. Gathering revised contributions presented at the international conference on Model-Based Reasoning (MBR023), held on June 7–9, 2023 in Rome, Italy, the book addresses various intertwined topics ranging from the epistemology and applications of models also concerning the problem of knowledge production and scientific methodology (information visualization, experimental methods, and design) to the analysis of their role in cognition, decision-making, also with respect to social implications. The problem of model-based cognition is also illustrated taking advantage of recent results regarding problem-solving, abduction, and logic, paying attention to a critique of the dominant and received approaches, to the aim of fostering new discussions and stimulate new ideas. All in all, the book provides researchers and graduate students in the fields of applied philosophy, epistemology, cognitive science, and artificial intelligence alike with an authoritative snapshot of the latest theories and applications of model-based reasoning.