Common diseases cost the developing world an enormous amount in terms of human life, health, and productivity, as well as lost economic potential. New and effective vaccines could not only improve the quality of life for millions of residents in developing countries, they could also contribute substantially to further economic development. Using data from the World Health Organization and other international agencies, this book analyzes disease burdens, pathogen descriptions, geographic distribution of diseases, probable vaccine target populations, alternative control measures and treatments, and future prospects for vaccine development. New Vaccine Development provides valuable insight into immunological and international health policy priorities.

Table of Contents


Front Matter
1. Summary
2. Priority Setting for Health-Related Investments: A Review of Methods
3. Overview of the Analytic Approach
4. Comparison of Disease Burdens
5. Predictions of Vaccine Development
6. Assessing the Likely Utilization of New Vaccines
7. Calculation and Comparison of the Health Benefits and Differential Costs Associated with Candidate Vaccines
8. Additional Issues in the Selection of Priorities for Accelerated Vaccine Development
9. Findings, Conclusions, and Recommendations
Appendix A: Selection of Vaccine Candidates for Accelerated Development
Appendix B: The Burden of Disease Resulting from Acute Respiratory Illness
Appendix C: The Burden of Disease Resulting from Diarrhea
Appendix D-1: The Prospects for Immunizing Against Dengue Virus
Appendix D-2: The Prospects for Immunizing Against Escherichia coli
Appendix D-3: The Prospects for Immunizing Against Hemophilus influenzae Type b
Appendix D-4: The Prospects for Immunizing Against Hepatitis A Virus
Appendix D-5: The Prospects for Immunizing Against Hepatitis B Virus
Appendix D-6: The Prospects for Immunizing Against Japanese Encephalitis Virus
Appendix D-7: The Prospects for Immunizing Against Mycobacterium leprae
Appendix D-8: The Prospects for Immunizing Against Neisseria meningitidis
Appendix D-9: The Prospects for Immunizing Against Parainfluenza Viruses
Appendix D-10: The Prospects for Immunizing Against Plasmodium spp.
Appendix D-11: The Prospects for Immunizing Against Rabies Virus
Appendix D-12: The Prospects for Immunizing Against Respiratory Syncytial Virus
Appendix D-13: The Prospects for Immunizing Against Rotavirus
Appendix D-14: The Prospects for Immunizing Against Salmonella typhi
Appendix D-15: The Prospects for Immunizing Against Shigella spp.
Appendix D-16: The Prospects for Immunizing Against Streptococcus Group A
Appendix D-17: The Prospects for Immunizing Against Streptococcus pneumoniae
Appendix D-18: The Prospects for Immunizing Against Vibrio cholerae
Appendix D-19: The Prospects for Immunizing Against Yellow Fever
Appendix E: Questionnaire for Assessing Morbidity-Mortality Trade-Offs
Appendix F: Technical Notes
Appendix G: Biographical Notes on Committee Members
Appendix H: Additional Sources of Advice to the Committee
Appendix I: Contents of Supplement to Volume II
Appendix J: Preface to Volume I
Appendix K: Contents to Volume I
Index