This two-volume set of LNCS 13393 and LNCS 13394 constitutes - in conjunction with the volume LNAI 13395 - the refereed proceedings of the 18th International Conference on Intelligent Computing, ICIC 2022, held in Xi'an, China, in August 2022. The 209 full papers of the three proceedings volumes were carefully reviewed and selected from 449 submissions.This year, the conference concentrated mainly on the theories and methodologies as well as the emerging applications of intelligent computing. Its aim was to unify the picture of contemporary intelligent computing techniques as an integral concept that highlights the trends in advanced computational intelligence and bridges theoretical research with applications. Therefore, the theme for this conference was “Advanced Intelligent Computing Technology and Applications”. Papers focused on this theme were solicited, addressing theories, methodologies, and applications in science and technology.