While recent developments in psychopharmacology have been widely disseminated, equally important advances in psychological strategies for severe mental health problems have received less attention. Filling a crucial gap in the literature, this volume brings together leading clinical scientists to present evidence-based approaches for treating schizophrenia, mood disorders, substance use problems, and severe personality disorders. Cutting-edge modalities presented include behavioral and cognitive-behavioral therapies, dynamic therapies, interpersonal therapies, couple and family treatments, motivational interviewing, and more. Throughout, step-by-step clinical guidelines are accompanied by illustrative case examples and patient-therapist dialogues. Particular attention is given to strategies for integrating psychological and pharmacological interventions, as well as to gender and cultural issues in treatment.