This issue of Sleep Medicine Clinics, Guest Edited by Max Hirshkowitz, PhD, D ABSM, will focus on Fatigue, with article topics including: Fatigue, Sleepiness, and Safety; Assessment, and Methodology; Fatigue and Neurological Disorders; Cardiopulmonary Disorders and Fatigue; Cancer and Fatigue; Psychiatric Disorders and Fatigue; Organ Transplantation and Fatigue; Fatigue in Other Medical Disorders; Sleep Disorders and Fatigue; The Pharmacology of Fatigue and Sleepiness; and Fatigue Management Strategies.