This book explores the critical role of acquisition, application, enhancement, and management of knowledge and human competence in the context of the largely digital and data/information dominated modern world. Whilst humanity owes much of its achievements to the distinct capability to learn from observation, analyse data, gain insights, and perceive beyond original realities, the systematic treatment of knowledge as a core capability and driver of success has largely remained the forte of pedagogy. In an increasingly intertwined global community faced with existential challenges and risks, the significance of knowledge creation, innovation, and systematic understanding and treatment of human competence is likely to be humanity's greatest weapon against adversity. This book was conceived to inform the decision makers and practitioners about the best practice pertinent to many disciplines and sectors. The chapters fall into three broad categories to guide the readers to gain insight from generic fundamentals to discipline-specific case studies and of the latest practice in knowledge and competence management.