modalities. The single most important fact about breast cancer is the great variation in its natural history and its responsiveness to therapy from one patient to another. The clinician must integrate an assessment of the patient's likely course based on clinical and pathological staging and laboratory studies with objective evidence on the benefits of therapy. The primary aim of this book is to provide the clinician with the tools to do just that. Outcomes of clinical trials and details about commonly used drug regimens, drug dosage, and the expected side effects are summarized in generous tables and figures. Medical terminology has been defined and descriptions of the evolution in our thinking and understanding of the disease are often given to provide perspective in the interpretation of evidence from current studies for busy clinicians and trainees alike.