In this issue of Clinics in Laboratory Medicine, guest editors Drs. Olga Pozdnyakova and Carlo Brugnara bring their considerable expertise to the topic of Hematology Laboratory in the Digital and Automation Age. Top experts in the field discuss how automation may be applied to hematology, coagulation, and flow cytometry; novel technologies for routine hematology and coagulation analysis to enhance readers’ knowledge of new digital technologies used for cell analysis and classification in hematology; and new uses of flow cytometry in the diagnosis of hematological malignancies, red cell disorders, and platelet function alterations.