The present work represents a unique undertaking in scientific publishing to honor Nick Metropolis, who passed away in October, 1999. Nick was the last survivor of the Manhattan Project that began during World War II in Los Alamos and later became the Los Alamos National Laboratory. In this volume, some of the leading scientists and humanists of our time have contributed essays related to their respective disciplines exploring various aspects of future developments in science, technology, and society. Speculations on the future developments of science and society, philosophy, national security, nuclear power, pure and applied mathematics, physics and biology, particle physics, computing, information science, among many others, are included. Contributors include: H. Agnew * R. Ashenhurst * K. Baclawski * G. Baker * N. Balazs * J.A. Freed * R. Hamming * M. Hawrylycz * O. Judd * D. Kleitman * M. Krieger * N. Krikorian * P. Lax * J.D. Louck * T. Puck * M. Raju * R. Richtmyer * J. Schwartz * R. Sokolowski * E. Teller * M. Waterman