All human activity in the world is an experiment of the inquiring mind. What is mind? Is mind visible? How does the mind work? There has been a lengthy tradition of inquiries in philosophy, psychology, mathematics, and cognitive science to answer these questions. In this multidisciplinary book, mathematician Matthew He provides integrative perspectives of algebraic biology, cognitive informatics, and poetic expressions of the human mind. Using classical Pythagorean Theorem and contemporary Category Theory, the proposed matrix models of the human mind connect three domains of the physical space of objective matters, mental space of subjective meanings, and emotional space of bijective modes; draws the connections between neural sparks and idea points, between synapses and idea lines, and between action potentials and frequency curves. Mathematics and life sciences come together in a unique way to navigate the black box of the human mind. These unique features offer broad audiences with multiple lenses to search for common patterns of human thoughts.