This collection of essays highlights Ancient, Byzantine and Medieval developments in the discussion of scientific method and argument in the comment(arie)s on Aristotle’s Posterior Analytics and related methodological passages in the Aristotelian corpus. Despite the importance of these discussions, the larger part of the commentary tradition on the Posterior Analytics still remains uncharted. The contributors to this volume identify and explore three important strands of interpretation, viz. (1) the reception of Aristotle’s logic of inquiry and theory of concept formation in Posterior Analytics II 19; (2) the influence of the Posterior Analytics on the evaluation of metaphysics as a science; and (3) the reception of Aristotle’s theory of demonstration, definition, and causation in Posterior Analytics book II.