The Handbook of Research on AI and ML for Intelligent Machines and Systems offers a comprehensive exploration of the pivotal role played by artificial intelligence (AI) and machine learning (ML) technologies in the development of intelligent machines. As the demand for intelligent machines continues to rise across various sectors, understanding the integration of these advanced technologies becomes paramount. While AI and ML have individually showcased their capabilities in developing robust intelligent machine systems and services, their fusion holds the key to propelling intelligent machines to a new realm of transformation. This handbook bridges the gap by presenting a comprehensive understanding of this fusion and its implications for the field. This book delves into the world of intelligent machines, revealing how they interact autonomously with their environment and adapt seamlessly to new situations. By harnessing the power of AI and ML, these smart devices can accomplish complex tasks such as traffic monitoring, speech recognition, face recognition, and automatic manufacturing, significantly enhancing operational efficiency. By compiling recent advancements in intelligent machines that rely on machine learning and deep learning technologies, this book serves as a vital resource for researchers, graduate students, PhD scholars, faculty members, scientists, and software developers. It offers valuable insights into the key concepts of AI and ML, covering essential security aspects, current trends, and often overlooked perspectives that are crucial for achieving comprehensive understanding. It not only explores the theoretical foundations of AI and ML but also provides guidance on applying these techniques to solve real-world problems. Unlike traditional texts, it offers flexibility through its distinctive module-based structure, allowing readers to follow their own learning paths.