Chloasma and vitiligo are refractory conditions of pigmentary skin disorders. Chloasma frequently occurs in adult females and the risk is higher during child bearing age. There are no ideal therapies available in biomedicine. Due to long term clinical experience, the pathology of chloasma has been interpreted in Chinese medicine and there is knowledge that the treatment of chloasma is based on harmonizing qi, blood, yin and yang, Vitiligo is a skin disease which is easy to diagnose since it involves depigmentation. However, it is hard to cure. Its mechanism is unclear and no effective treatments have been established to date in biomedicine. Recently, this disease has been shown to be associated with deficiency of liver and kidney, qi stagnation and blood stasis. Therefore, the principles of nourishing liver and kidney, invigorating blood to dispel stasis and regulating qi and blood are applied to achieve a positive therapeutic effect.