Although most universities could be considered bureaucrat organizations, the accumulated knowledge reveals that universities try to adapt their core activities and technological innovation processes to face the current socio-economic challenges. This book explores the ways in which universities have re-built multiple capabilities to support the development of applied innovation and manage new technologies. Concretely, this book (1) theoretically addresses the university managers’ view for re-building university capabilities due to the public policy agendas demands; and (2) empirically addresses the documentation of experiences and strategies adopted by universities in different contexts to achieve public policy agendas. These universities strategies include re-build entrepreneurial, innovative, digital, and sustainable capabilities. This book encourages researchers, scholars, academics, students and policy makers to re-think how universities are expanding equal opportunities relatedto high-quality higher education, innovative/entrepreneurial graduate options, and contributing to sustainable societal advance and well-being through research and community engagement.